Interventions Relieving Dyspnea in Intubated Patients Show Responsiveness of the Mechanical Ventilation–Respiratory Distress Observation Scale
Maxens Decavèle, Côme Bureau, Sébastien Campion, Marie‐Cécile Nierat, Isabelle Rivals, Nicolas Wattiez, Morgane Faure, Julien Mayaux, Élise Morawiec, Mathieu Raux, Thomas Similowski, Alexandre Demoule
Abstract
Abstract Rationale Breathing difficulties are highly stressful. In critically ill patients, they are associated with an increased risk of posttraumatic manifestations. Dyspnea, the corresponding symptom, cannot be directly assessed in noncommunicative patients. This difficulty can be circumvented using observation scales such as the mechanical ventilation–respiratory distress observation scale (MV-RDOS). Objective To investigate the performance and responsiveness of the MV-RDOS to infer dyspnea in noncommunicative intubated patients. Methods Communicative and noncommunicative patients exhibiting breathing difficulties under mechanical ventilation were prospectively included and assessed using a dyspnea visual analog scale, MV-RDOS, EMG activity of alae nasi and parasternal intercostals, and EEG signatures of respiratory-related cortical activation (preinspiratory potentials). Inspiratory-muscle EMG and preinspiratory cortical activities are surrogates of dyspnea. Assessments were conducted at baseline, after adjustment of ventilator settings, and, in some cases, after morphine administration. Measurements and Main Results Fifty patients (age, 67 [(interquartile interval [IQR]), 61–76] yr; Simplified Acute Physiology Score II, 52 [IQR, 35–62]) were included, 25 of whom were noncommunicative. Relief occurred in 25 (50%) patients after ventilator adjustments and in 21 additional patients after morphine administration. In noncommunicative patients, MV-RDOS score decreased from 5.5 (IQR, 4.2–6.6) at baseline to 4.2 (IQR, 2.1–4.7; P < 0.001) after ventilator adjustments and 2.5 (IQR, 2.1–4.2; P = 0.024) after morphine administration. MV-RDOS and alae nasi/parasternal EMG activities were positively correlated (ρ = 0.41 and 0.37, respectively). MV-RDOS scores were higher in patients with EEG preinspiratory potentials (4.9 [IQR, 4.2–6.3] vs. 4.0 [IQR, 2.1–4.9]; P = 0.002). Conclusions The MV-RDOS seems able to detect and monitor respiratory symptoms reasonably well in noncommunicative intubated patients. Clinical trial registered with www.clinicaltrials.gov (NCT 02801838).