Trehalose activates autophagy to alleviate cisplatin-induced chronic kidney injury by targeting the mTOR-dependent TFEB signaling pathway
Jingchao Yang, Longhui Yuan, Lan Li, Liu Fei, Jingping Liu, Younan Chen, Ping Fu, Yanrong Lu, Yujia Yuan
Abstract
Our findings suggested that trehalose induced autophagy to alleviate cisplatin-induced chronic kidney injury by targeting the mTOR-dependent TFEB signaling pathway.
Topics & Concepts
AutophagyTFEBPI3K/AKT/mTOR pathwayCell biologyULK1Signal transductionCisplatinChemistryTrehaloseKidneyCancer researchPharmacologyMedicineBiologyKinaseBiochemistryProtein kinase AApoptosisInternal medicineAMPKChemotherapyTuberous Sclerosis Complex Research