Interconnected Dynamics Among Inflammation, Immunity, and Cancer–From Tumor Suppression to Tumor Onset, Promotion, and Progression
Elena-Teodora Tâlvan, Liviuţa Budişan, Călin Ilie Mohor, Valentin Grecu, Ioana Berindan-Neagoe, Victor Cristea, George-Călin Oprinca, Adrian Nicolae Cristian
Abstract
Inflammation serves as the body’s defensive response to harmful stimuli. In the acute phase, immune cells such as neutrophils—which act as the principal responders—along with NK cells, DCs, and macrophages, secrete inflammatory mediators including cytokines, growth factors, and proteolytic enzymes, thereby facilitating tissue repair and regeneration. However, when this response becomes chronic, macrophages become the dominant immune population, succeeded by T and B cells, leading to the continuo
Topics & Concepts
Immune systemInflammationSecretionCancer researchCell biologyDynamics (music)BiologyTumor cellsImmunologyTumor progressionMacrophageMedicineInnate immune systemImmunityInflammatory responseTumor microenvironmentTissue repairChemistryCytokineImmune cells in cancerAtherosclerosis and Cardiovascular DiseasesCancer Immunotherapy and Biomarkers