IBX-Promoted Oxidative Cyclization of <i>N</i>-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines
Peng Gao, Huaijuan Chen, Zijing Bai, Mi‐Na Zhao, De‐Suo Yang, Juan Wang, Ning Wang, Lele Du, Zheng‐Hui Guan
Abstract
-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alcohol, followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.
Topics & Concepts
ChemistryAldehydeReagentEnvironmentally friendlyAlcoholOrganic chemistrySubstrate (aquarium)Oxidative phosphorylationEnamineCombinatorial chemistryCondensationCondensation reactionSelectivityMetalCatalysisThermodynamicsOceanographyBiochemistryPhysicsGeologyEcologyBiologyOxidative Organic Chemistry ReactionsSynthesis and Characterization of PyrrolesCatalytic C–H Functionalization Methods