Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and <i>in vitro</i> inhibition of amyloid β <sub>1–42</sub> peptide aggregation, acetylcholinesterase and carbonic anhydrase-II
Ayesha Tahir, Bushra Mobeen, Fahad Hussain, Abdul Sadiq, Umer Rashid
Abstract
peptide (PDB ID = 1IYT) showed significant interactions with amino acid residues Asp 23 and Lys 28, and hydrophobic interactions with the Phe19, Phe20, and Ala 30 effectively impeding the formation of β-sheet structures.
Topics & Concepts
AcetylcholinesteraseIn vitroPregnenoloneCarbonic anhydraseChemistryPeptideAmyloid (mycology)Biochemistryβ amyloidEnzymeInternal medicineAlzheimer's diseaseDiseaseMedicineInorganic chemistrySteroidHormoneCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibitionPhosphodiesterase function and regulation