Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx
Rabia Avcibas, Anna Vermul, Vladimir Gluhovic, Nico Boback, Raquel Arroyo, Paul S. Kingma, Miriam Isasi-Campillo, Lucía Garciá‐Ortega, Matthias Griese, Wolfgang M. Kuebler, Matthias Ochs, Daniel Lauster, Elena López-Rodríguez
2024American Journal of Physiology-Lung Cellular and Molecular Physiology11 citationsDOIOpen Access PDF
Abstract
SP-A and SP-D function has been related to innate immunity of the lung based on their binding to sugar residues at pathogen surfaces. However, their function in the healthy alveolus was considered as limited to interaction with surfactant lipids. Here, we demonstrated that these proteins bind to glycosaminoglycans present at typical cell surfaces like the alveolar epithelial glycocalyx. We propose a model where these proteins play an important role in interconnecting alveolar epithelial glycocalyx components.
Topics & Concepts
GlycocalyxGlycosaminoglycanSulfationChemistryPulmonary surfactantCalciumAlveolar EpitheliumCell biologyBiochemistryBiophysicsEpitheliumBiologyPathologyMedicineOrganic chemistryNeonatal Respiratory Health ResearchErythrocyte Function and PathophysiologyProteoglycans and glycosaminoglycans research