Acinetobacter baumannii GC2 Sublineage Carrying the <i>aac</i> ( <i>6</i> ′)- <i>Im</i> Amikacin, Netilmicin, and Tobramycin Resistance Gene Cassette
Christopher J. Harmer, Steven J. Nigro, Ruth M. Hall
Abstract
, which confers resistance to gentamicin. These two genes are commonly found together in GC2 complete and draft genomes and globally distributed. One isolate appears to be ancestral, as its genome contains few ISAba1 copies, providing insight into the original source of this insertion sequence (IS), which is abundant in most GC2 isolates. Tracking ISAba1 spread can provide a simple means to track the development and ongoing evolution as well as the dissemination of specific lineages and detect the formation of many sublineages. The complete ancestral genome will provide an essential base point for tracking this process.
Topics & Concepts
NetilmicinTobramycinAmikacinAcinetobacter baumanniiAminoglycosideBiologyGentamicinMicrobiologyMedicineVirologyAntibioticsGeneticsPseudomonas aeruginosaBacteriaAntibiotic Resistance in BacteriaMalaria Research and ControlDrug Transport and Resistance Mechanisms