Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway
Zhengjian Wang, Jin Liu, Fan Li, Shurong Ma, Liang Zhao, Peng Ge, Haiyun Wen, Yibo Zhang, Xiaojun Liu, Yalan Luo, Jiaqi Yao, Guixin Zhang, Hailong Chen
Abstract
). In addition, The AMPK/NF-κB/NLRP3 pathway mediated by SCFAs along the gut-lung axis may play an essential role in preventing the pathogenesis of SAP-ALI, which allows for reduced systemic inflammation and restoration of the intestinal barrier.
Topics & Concepts
Gut floraButyrateFirmicutesAcute pancreatitisLipopolysaccharideAMPKMedicineMicrobiologyImmunologyBacteriaBiologyInternal medicineBiochemistryProtein kinase AEnzyme16S ribosomal RNAGeneticsFermentationPancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchChildhood Cancer Survivors' Quality of Life