Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes
Kara Garrott, Savannah Bifulco, David A. Ramirez, Brendan Koop
Abstract
As pulsed-field ablation (PFA) emerges as a promising therapy for atrial arrhythmias, an understanding of the cellular injury to cardiac tissue is critical to evaluating and interpreting results for each PFA system. This review aims to detail the mechanism of cell death for PFA, compare the cell death mechanism to thermal ablation modalities, clarify common histology markers, detail the progression of PFA lesions from the acute, to subacute, to chronic maturation states, and discuss clinical indicators of PFA lesions.
Topics & Concepts
MedicineAblationLesionMechanism (biology)PathologyRadiologyCardiologyPhilosophyEpistemologyAtrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments