Discovery of novel thiazolopyrimidine derivatives targeting topoisomerase II: Design, synthesis, antiproliferative evaluation, molecular docking and apoptosis inducing activity
Sara Y Ewieda, Mo’men Salem, Ahmed Elshewy, Mohnad Abdalla, May A. El‐Manawaty, Hoda Khalifa Abd-Elhady, Haredy Hassan Haredy, Wael A. A. Fadaly, Mamdouh F. A. Mohamed, Mohamed T. M. Nemr
Topics & Concepts
ChemistryEtoposideIC50TopoisomeraseDoxorubicinApoptosisDocking (animal)Cell cycleCancer cellCell cycle checkpointStereochemistryCytotoxic T cellCell growthPharmacologyBiochemistryCancerEnzymeIn vitroChemotherapyBiologyGeneticsNursingMedicineCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and bioactivity of alkaloids