Revisiting the Hallmarks of Aging to Identify Markers of Biological Age
Florent Guerville, Philipe de Souto Barreto, Isabelle Ader, Sandrine Andrieu, Louis Casteilla, Cédric Dray, Nicolas Fazilleau, Sophie Guyonnet, Dominique Langin, Roland Liblau, Angelo Parini, Philippe Valet, Nathalie Vergnolle, Yves Rolland, Bruno Vellas
Abstract
The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life expectancy in healthy aging is not increasing as fast as lifespan. The identification of biomarkers of aging is critical to predict adverse outcomes during aging, to implement interventions to reduce them, and to monitor the response to these interventions. In this narrative review, we gathered information about biomarkers of aging under the perspective of Geroscience. Based on the current literature, for each hallmark of biological aging, we proposed a putative biomarker of healthy aging, chosen for their association with mortality, age-related chronic diseases, frailty and/or functional loss. We also discussed how they could be validated as useful predictive biomarkers.