Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design
Zhen Zhang, Yongjin Wang, Xiaojuan Chen, Xiaojuan Song, Zhengchao Tu, Yongheng Chen, Zhimin Zhang, Ke Ding
Topics & Concepts
ChemistryMoietyCovalent bondTrifluoromethylWarheadKetoneCombinatorial chemistryResidue (chemistry)CysteineStereochemistryEnzymeBiochemistryOrganic chemistryEngineeringAerospace engineeringAlkylChronic Myeloid Leukemia TreatmentsFibroblast Growth Factor ResearchPeptidase Inhibition and Analysis