Green Approach of Solvent- and Catalyst Free Synthesis of Bis(indolyl)methanes under Visible Light Irradiation
Baliram S. Hote, Tabbasum A. J. Siddiqui, Parshuram M. Pisal, Gajanan G. Mandawad
Abstract
An efficient procedure has been developed for the synthesis of bis(indolyl)methanes (3a-m) from condensation of indole (1) and various substituted aromatic aldehydes (2a-m) is described. The aromatic electrophilic substitution reactions of indole (1) with and various substituted aromatic aldehydes (2a-m) are achieved in solvent- and catalyst free condition using irradiation with 150W tungsten lamp (visible light irradiation). This methodology offers several advantages such as good yields, simple procedure, mild and environmentally benign conditions.
Topics & Concepts
ChemistryCatalysisIndole testElectrophilic aromatic substitutionElectrophilic substitutionVisible spectrumCondensationSolventIrradiationTungstenOrganic chemistryGreen chemistryPhotochemistryCombinatorial chemistryReaction mechanismOptoelectronicsPhysicsThermodynamicsNuclear physicsSynthesis of Indole DerivativesMulticomponent Synthesis of HeterocyclesChemical Synthesis and Reactions