Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples
Elisa Napoli, Vilde Yuli Stenberg, Asta Juzeniene, Gro E. Hjellum, Øyvind S. Bruland, Roy H. Larsen
Abstract
Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium with progeny, when it comes to preclinical and clinical trials. In this study, 212Pb activity was determined using a high purity germanium (HPGe) detector, which allowed the determination of geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) and sodium iodide (NaI) detectors.
Topics & Concepts
Semiconductor detectorCalibrationSodium iodideDetectorGermaniumIonizationRadiochemistryRadionuclidePhysicsMaterials scienceAnalytical Chemistry (journal)ChemistryNuclear physicsOpticsOptoelectronicsChromatographyIonSiliconQuantum mechanicsRadiopharmaceutical Chemistry and ApplicationsRadioactive Decay and Measurement TechniquesRadiation Therapy and Dosimetry