Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia
T. Alexopoulos, Larisa Vasilieva, Meropi Kontogianni, Ρωξάνη Τέντα, Alexandra Georgiou, Evangelia Stroumpouli, Iliana Mani, Αlexandra Alexopoulou
Abstract
Serum levels of myostatin were significantly lower in cirrhotic patients with impaired skeletal mass index (SMI) and sarcopenia than those without. Serum levels of myostatin have a positive correlation with SMI. Myostatin levels are independently associated with sarcopenia, diagnosed according to the latest criteria, in patients with cirrhosis. Myostatin in combination with creatine phosphokinase or albumin have good accuracy excluding sarcopenia in patients with cirrhosis.
Topics & Concepts
MyostatinSarcopeniaCirrhosisInternal medicineMedicineCreatine kinaseAlbuminBody mass indexEndocrinologyGastroenterologySkeletal muscleNutrition and Health in AgingHIV-related health complications and treatmentsMuscle Physiology and Disorders