Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo
Nairong Yu, Na Li, Kun Wang, Qi Deng, Zhichao Lei, Jianbo Sun, Li Chen
Topics & Concepts
MCF-7ChemistryIn vivoScopoletinApoptosisProtein kinase BPI3K/AKT/mTOR pathwayIn vitroCytotoxicityCell cultureNitric oxideCancer cellCell cyclePharmacologyCell cycle checkpointBiological activityPhosphorylationCancerBiochemistryHuman breastBiologyInternal medicineMedicineAlternative medicineOrganic chemistryBiotechnologyGeneticsPathologyBioactive Compounds and Antitumor AgentsMorinda citrifolia extract usesSynthesis and biological activity