FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
Kaiping Deng, Yixuan Fan, Yaxu Liang, Yu Cai, Guomin Zhang, Mingtian Deng, Zhibo Wang, Jiawei Lu, Jianfei Shi, Feng Wang, Yanli Zhang
Abstract
mRNA drives skeletal muscle differentiation by activating the p38 MAPK pathway, which provides a molecular mechanism for the regulation of myogenesis via RNA methylation.
Topics & Concepts
MyogenesisChemistryp38 mitogen-activated protein kinasesDemethylationCell biologyMAPK/ERK pathwayBiologySignal transductionMyocyteBiochemistryGeneGene expressionDNA methylationRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing