Surface functionalization strategies of ROS-scavenging nanozymes for synergistic therapy and efficient delivery
Xinyue Wu, Yiyun Zhang, Peipei Xing, Mengliang Zhu
Abstract
retention, and facilitates controlled release. Drug-loading strategies further expand the therapeutic potential by enabling co-delivery of antioxidants and other functional agents to complex pathological environments. Despite these promising advancements, challenges remain in elucidating the fundamental catalytic mechanisms of nanozymes, ensuring long-term biocompatibility, and achieving scalable clinical translation. Future efforts should focus on developing dynamically responsive systems, achieving precision catalysis, and fostering interdisciplinary integration to accelerate the evolution of nanozyme-based therapeutics. This review systematically summarizes the modification strategies from a surface perspective, offering insights for constructing multifunctional systems.