T <sub>H</sub> 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity
Stacey N. Harbour, Daniel DiToro, Steven Witte, Carlene L. Zindl, Min Gao, Trenton R. Schoeb, Gareth W. Jones, Simon A. Jones, Robin D. Hatton, Casey T. Weaver
Abstract
Ongoing classic IL-6 receptor signaling is required to maintain the T H 17 program, acting upstream of IL-23 to sustain RORγt expression.
Topics & Concepts
Signal transductionCell biologySTAT3BiologyInterleukin 17PhenotypeCell signalingCellInterleukin 9Transcription factorInterleukin 23ImmunologyInterleukinInflammationCytokineGeneGeneticsImmunodeficiency and Autoimmune DisordersIL-33, ST2, and ILC PathwaysPsoriasis: Treatment and Pathogenesis