Small-Molecule Compound CY-158-11 Inhibits Staphylococcus aureus Biofilm Formation
Li Shen, Jiao Zhang, Yao Chen, Lulin Rao, Xinyi Wang, Huilin Zhao, Bingjie Wang, Yanghua Xiao, Jingyi Yu, Yanlei Xu, Junhong Shi, Weihua Han, Zengqiang Song, Fangyou Yu
Abstract
Most bacteria exist in the form of biofilms, often strongly adherent to various surfaces, causing bacterial resistance and chronic infections. In general, antibacterial drugs are not effective against biofilms. The small-molecule compound CY-158-11 inhibited the biofilm formation of S. aureus at a subinhibitory concentration. By hindering adhesion and PIA-mediated biofilm formation, CY-158-11 exhibits antibiofilm activity toward S. aureus. These findings point to a novel therapeutic agent for combating intractable S. aureus-biofilm-related infections.
Topics & Concepts
Staphylococcus aureusBiofilmMicrobiologyChemistryBiologyBacteriaGeneticsBacterial biofilms and quorum sensingAntimicrobial agents and applicationsAntimicrobial Resistance in Staphylococcus