Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma
Jakob Stokholm, Jonathan Thorsen, Martin J. Blaser, Morten Arendt Rasmussen, Mathis Hjort Hjelmsø, Shiraz A. Shah, E. D. Christensen, Bo Chawes, Klaus Bønnelykke, Susanne Brix, Martin Steen Mortensen, Asker Brejnrod, Gisle Vestergaard, Urvish Trivedi, Søren J. Sørensen, Hans Bisgaard
Abstract
rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.