Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy
Thomas Müller, Sebastian Jarosch, Monika Hammel, Justin Leube, Simon Grassmann, Bettina E. Bernard, Manuel Effenberger, Immanuel Andrä, M. Zeeshan Chaudhry, Theresa Käuferle, Antje Malo, Luka Čičin‐Šain, Peter Steinberger, Tobias Feuchtinger, Ulrike Protzer, Kathrin Schumann, Michael Neuenhahn, Kilian Schober, Dirk H. Busch
Abstract
T cell responses, which represents a crucial aspect for clinical application in adoptive T cell immunotherapy.
Topics & Concepts
ImmunotherapyFunction (biology)Genome editingGeneReceptorComputational biologyCellChimeric antigen receptorProduct (mathematics)BiologyCell biologyGeneticsGenomeImmune systemMathematicsGeometryCAR-T cell therapy researchVirus-based gene therapy researchCRISPR and Genetic Engineering