A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich’s ataxia
Oscar A. Campos, Narsis Attar, Chen Cheng, Maria Vogelauer, Nathan V. Mallipeddi, Stefan Schmollinger, Nedas Matulionis, Heather R. Christofk, Sabeeha Merchant, Siavash K. Kurdistani
Abstract
Reduction of Cu 1+ production by histone H3 restores cellular deficiencies caused by insufficient supply of iron-sulfur clusters.
Topics & Concepts
AtaxiaYeastCopperHistoneHistone H3BiochemistryChemistryReductaseReduction (mathematics)EnzymeCell biologyBiologyNeuroscienceGeneGeometryOrganic chemistryMathematicsGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyFungal and yeast genetics research