Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature
Sakshi Bami, Jennifer Hidinger, Arshia Madni, Virginia Hargest, Stacey Schultz‐Cherry, Valerie Cortez, Shane J. Cross, Deborah Ward, Randall T. Hayden, Jeffrey E. Rubnitz, Ching‐Hon Pui, Raja B. Khan, Diego R. Hijano
Abstract
Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology.
Topics & Concepts
AstrovirusMedicineEncephalitisEtiologyMetagenomicsCerebrospinal fluidVirologyPathologyVirusGeneBiologyGeneticsRotavirusViral gastroenteritis research and epidemiologyVirus-based gene therapy researchViral Infections and Immunology Research