Catheter-based left atrial appendage CLOSURE in patients with atrial fibrillation at high risk of stroke and bleeding as compared to best medical therapy: Rationale and design of the prospective randomized CLOSURE-AF trial

Ulf Landmesser, Carsten Skurk, Paulus Kirchhof, Thorsten Lewalter, Johannes Hartung, Andi Rroku, Burkert Pieske, Johannes Brachmann, İbrahim Akın, Claudius Jacobshagen, Benjamin Meder, Andreas M. Zeiher, Stefan D. Anker, Holger Thiele, Stefan Blankenberg, Steffen Maßberg, Heribert Schunkert, Norbert Frey, Alexander Joost, Martin Bergmann, Karl Georg Hæusler, Matthias Endres, Karl Wegscheider, Leif‐Hendrik Boldt, Ingo Eitel