Rapamycin-encapsulated costimulatory ICOS/CD40L-bispecific nanoparticles restrict pathogenic helper T-B-cell interactions while in situ suppressing mTOR for lupus treatment
Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang, Zhihua Wu, Huihua Ding, Nan Shen, Yourong Duan
Topics & Concepts
T cellImmune systemSystemic lupus erythematosusCD40PI3K/AKT/mTOR pathwayImmunologyCancer researchCell biologyBiologyMedicineSignal transductionCytotoxic T cellIn vitroInternal medicineDiseaseBiochemistryT-cell and B-cell ImmunologyImmune Cell Function and InteractionSystemic Lupus Erythematosus Research