Biodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophages
Guowen Luo, Ziyang Xu, Hua Zhong, Hongwei Shao, Hongyi Liao, Nan Liu, Xulin Jiang, Yu Zhang, Xiongfa Ji
Abstract
, the local administration of HTA + NIR exerted photothermal killing of primary tumors and reprogramming of TAMs into M1-type macrophages in the TME. Therefore, the injectable photothermally active antitumor hydrogel has great potential for modulating the TME to treat bone tumors.
Topics & Concepts
Self-healing hydrogelsReprogrammingPhotothermal therapyOsteosarcomaChemistryCell biologyBiophysicsCancer researchNanotechnologyBiochemistryMaterials scienceCellBiologyPolymer chemistryNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseImmune cells in cancer