<i>Bacteroides thetaiotaomicron</i> and <i>Faecalibacterium prausnitzii</i> served as key components of fecal microbiota transplantation to alleviate colitis
Binqiang Xu, Yang Fu, Nuoming Yin, Wenfei Qin, Zehua Huang, Wei Xiao, Huizhen Huang, Qixiang Mei, Junjie Fan, Yue Zeng, Chunlan Huang
2024American Journal of Physiology-Gastrointestinal and Liver Physiology21 citationsDOIOpen Access PDF
Abstract
We demonstrate that donors with high abundance of Bacteroides and Faecalibacterium ameliorate dextran sulfate sodium (DSS)-induced colitis in mice by fecal microbiota transplantation (FMT). The combination therapy of Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii is superior to mono-bacterial therapy in ameliorating colitis in mice, of which mechanism may involve promoting lecithin and inducing IL-10 production of intestinal Tregs.
Topics & Concepts
Bacteroides thetaiotaomicronFaecalibacterium prausnitziiColitisMicrobiomeBifidobacteriumInflammatory bowel diseaseBacteroidesFecesMicrobiologyImmune systemImmunologyGut floraBiologyMedicineBacteriaInternal medicineLactobacillusDiseaseBioinformaticsGeneticsClostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders