Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
Moon Jong Kim, Yuanjian Huang, Jae‐Il Park
Abstract
Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.
Topics & Concepts
Wnt signaling pathwayCarcinogenesisCancer researchSignal transductionRegeneration (biology)BioinformaticsMedicineBiologyCancerCell biologyInternal medicineWnt/β-catenin signaling in development and cancerCancer-related gene regulationCancer Mechanisms and Therapy