EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway
Nan Zhu, Haochen Guan, Xuan Wang, Yueyue Zhang, Lijie Gu, Jieshuang Jia, Ling Wang, Weijie Yuan
Abstract
Thus, this study indicated that EZH2 is involved in IL-6/sIL-6R signalling and epigenetically regulates SP4 expression, thereby stimulating VEGF production and angiogenesis in PD. Targeting EZH2 is expected to be a novel therapeutic approach for end-stage renal disease (ESRD) patients with PD treatment.
Topics & Concepts
AngiogenesisEZH2Vascular endothelial growth factorCancer researchGene silencingBiologyDNA methylationChemistryCell biologyMethylationGene expressionBiochemistryGeneVEGF receptorsEpigenetics and DNA MethylationDialysis and Renal Disease ManagementPregnancy and preeclampsia studies