Organocatalytic Friedel–Crafts arylation of aldehydes with indoles utilizing N-heterocyclic iod(az)olium salts as halogen-bonding catalysts
Eirini M. Galathri, Thomas J. Kuczmera, Boris J. Nachtsheim, Christoforos G. Kokotos
Abstract
Halogen-bonding catalysis enables the organocatalytic Fridel–Crafts arylation of aldehydes with indoles.
Topics & Concepts
CatalysisChemistryHalogenFriedel–Crafts reactionHalogen bondOrganic chemistryOrganocatalysisSynergistic catalysisCombinatorial chemistryPolymer chemistryEnantioselective synthesisAlkylSynthesis of Indole DerivativesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods