Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation
Tzu-Cheng Sung, Ting Wang, Qian Liu, Qing‐Dong Ling, Suresh Kumar, Remya Rajan Renuka, Shih-Tien Hsu, Akihiro Umezawa, Akon Higuchi
Abstract
integrin receptors, many peptides have been developed that bind to specific integrin receptors. In this review, we discuss the peptide sequence, immobilization design, reaction method, and functions of several ECM protein-derived peptides. Various peptide sequences derived from mainly ECM proteins, which are used for coating or grafting on dishes, scaffolds, hydrogels, implants or nanofibers, have been developed to improve the adhesion, proliferation or differentiation of stem cells and to culture differentiated cells. This review article will help to inform the optimal choice of ECM protein-derived peptides for the development of scaffolds, implants, hydrogels, nanofibers and 2D cell culture dishes to regulate the proliferation and direct the differentiation of stem cells into specific lineages.