Access to Phosphine-Containing Quinazolinones Enabled by Photo-Induced Radical Phosphorylation/Cyclization of Unactivated Alkenes
Binsong Mu, Le Zhang, Guanghui Lv, Kang Chen, Ting Wang, Jian Chen, Tianle Huang, Li Guo, Zhongzhen Yang, Yong Wu
Abstract
A mild and facile photo-induced cascade radical addition/cyclization of unactivated alkenes has been reported, through which a variety of biologically valuable phosphine-containing quinazolinones could be obtained in moderate to good yields. The protocol was characterized by mild conditions, broad substrate scope, and high atomic economy.
Topics & Concepts
ChemistryPhosphineScope (computer science)Combinatorial chemistrySubstrate (aquarium)Radical cyclizationCascadePhosphorylationOrganic chemistryCatalysisBiochemistryChromatographyOceanographyComputer scienceGeologyProgramming languageRadical Photochemical ReactionsQuinazolinone synthesis and applicationsSulfur-Based Synthesis Techniques