Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma
Yao Li, Fengwei Li, Lei Xu, Xiaodong Shi, Hui Xue, Jianwei Liu, Shilei Bai, Yeye Wu, Yang Zhao, Feng Xue, Yong Xia, Hui Dong, Feng Shen, Kui Wang
Abstract
The profiles of immune TMEs showed differences in HCC patients responsive, non-responsive and untreated. These differences might explain the discounted efficacy of immunotherapy in some HCC patients. The cells and molecules, which we found to carry unique capabilities, may be targeted to enhance immunotherapeutic outcomes in patients with HCC.
Topics & Concepts
Hepatocellular carcinomaBlockadeImmune systemPD-L1CellCancer researchMedicineImmunologyChemistryInternal medicineImmunotherapyReceptorBiochemistryCancer Immunotherapy and BiomarkersImmune cells in cancerImmune Cell Function and Interaction