The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects of<i>Lithocarpus polystachyus</i>(sweet tea) on APAP-induced oxidative stress injury in mice
Jiayu Yang, Yu-te Zhong, Wei-Nan Hao, Xiang-xiang Liu, Qiong Shen, Yan-fei Li, Shen Ren, Zi Wang, Wei Li, Lichun Zhao
Abstract
< 0.05). Moreover, STL-E partially mitigated APAP-induced liver injury by effectively activating the PI3K/Akt pathway and inhibiting the NF-κB pathway. In a word, STL-E protected liver against APAP-induced hepatotoxicity by inhibiting the PI3K/Akt-mediated apoptosis signal pathway and inhibiting the NF-κB-mediated signaling pathway.
Topics & Concepts
Oxidative stressProtein kinase BNF-κBPI3K/AKT/mTOR pathwayChemistryPharmacologySignal transductionMedicineBiochemistryPhytoestrogen effects and researchNatural Antidiabetic Agents StudiesBiochemical Acid Research Studies