Visible-Light-Promoted Intermolecular β-Acyl Difunctionalization of Alkenes via Oxidative Radical-Polar Crossover
Hao‐Cong Li, Ke-Yuan Zhao, Yan Tan, Hao-Sen Wang, Wenshan Wang, Xiaolan Chen, Bing Yu
Abstract
A visible-light-induced β-acyl difunctionalization of alkenes with acyl oxime esters and various nucleophiles was developed to achieve molecular complexity from readily available raw materials via oxidative radical-polar crossover. A variety of nucleophiles, including N H-sulfoximines, indoles, indazole, and trimethoxybenzene, were all effectively applicable to the sustainable reaction system. The novel synthetic strategy features mild reaction conditions, a broad substrate scope (39 examples), easy scale-up, and excellent regioselectivity.
Topics & Concepts
ChemistryNucleophileRegioselectivityCombinatorial chemistryIntermolecular forceSubstrate (aquarium)OximeOxidative phosphorylationRadicalOrganic chemistryPhotochemistryMoleculeCatalysisBiochemistryGeologyOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques