Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8 <sup>+</sup> T-Cell Epitopes Identified in COVID-19 Convalescent Individuals
Andrew D. Redd, Alessandra Nardin, Hassen Kared, Evan M. Bloch, Brian Abel, Andrew Pekosz, Oliver Laeyendecker, Michael Fehlings, Thomas C. Quinn, Aaron A.R. Tobian
Abstract
T-cell response in 30 individuals who recovered from COVID-19 in 2020 were mutated in the Omicron variant. Only one of 52 epitopes identified in this population contained an amino acid that was mutated in Omicron. These data suggest that the T-cell immune response in previously infected, and most likely vaccinated, individuals should still be effective against Omicron.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakBiologyMutationEpitopeGeneticsMedicineAntibodyGeneDiseaseInfectious disease (medical specialty)OutbreakPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches