A new cyclic peptide from the fibrous root of <i>Pseudostellaria heterophylla</i>
Xiaofei Zhao, Qian Zhang, Han-Tao Zhao, Yan-da Zhang, Hanru Liu, Lujiang Yuan, Qianfeng Chen
Abstract
A new cyclic peptide, Pseudostellarin K (1), together with thirteen known compounds, including two cyclic peptides (2 and 3), one β-carboline alkaloid (4), two amides (5 and 6), three phenylpropanoids (7–9) and other compounds (10–14), were isolated from the fibrous root of Pseudostellaria heterophylla. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4–6, 10 were isolated from the genus pseudostellaria for the first time. All compounds were evaluated for cytotoxic activities against MCF-7, A549, HCT-116 and SGC-7901 cell lines by MTT assay. Unfortunately, all these compounds displayed weak cytotoxic activities.
Topics & Concepts
AlkaloidCyclic peptideChemistryPeptideCytotoxic T cellCytotoxicityMTT assayStereochemistryIn vitroBiochemistryAgriculture and Biological StudiesMedicinal plant effects and applicationsMoringa oleifera research and applications