MicroRNAs as therapeutic targets in cardiovascular disease
Bernhard Laggerbauer, Stefan Engelhardt
Abstract
The discovery of microRNAs and their role in diseases was a breakthrough that inspired research into microRNAs as drug targets. Cardiovascular diseases are an area in which limitations of conventional pharmacotherapy are highly apparent and where microRNA-based drugs have appreciably progressed into preclinical and clinical testing. In this Review, we summarize the current state of microRNAs as therapeutic targets in the cardiovascular system. We report recent advances in the identification and characterization of microRNAs, their manipulation and clinical translation, and discuss challenges and perspectives toward clinical application.
Topics & Concepts
microRNADiseaseBioinformaticsMedicineTranslation (biology)PharmacotherapyComputational biologyTranslational researchBiologyPathologyInternal medicineGeneticsMessenger RNAGeneMicroRNA in disease regulationCircular RNAs in diseasesRNA Interference and Gene Delivery