The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response
Anne-Emmanuelle Roux, Sylvie Robert, Mathilde Bastat, Isabelle Rosinski‐Chupin, Vanessa Rong, Sébastien Holbert, Laurent Méreghetti, Émilie Camiade
Abstract
Streptococcus agalactiae is a major cause of disease burden leading to morbidity and mortality in neonates worldwide. Deciphering its adaptation mechanisms is essential to understand how this bacterium manages to colonize its host. Here, we determined the regulon of the pleiotropic regulator CcpA in S. agalactiae. Our findings reveal that CcpA is not only involved in carbon catabolite repression, but is also important for acidic and oxidative stress resistance and survival in macrophages.
Topics & Concepts
CCPACatabolite repressionStreptococcus agalactiaeBiologyMicrobiologyFed-batch cultureRegulatorBacteriaGeneBiochemistryStreptococcusGeneticsMutantFermentationNeonatal and Maternal InfectionsStreptococcal Infections and TreatmentsPneumonia and Respiratory Infections