Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis
Weijie Wang, Jinxuan Yang, Pinfang Kang, Jinsong Bai, Xiaoli Feng, Liuqi Huang, Yiming Zhang, Yi‐Rui Wu, Bi Tang, Hongju Wang, JianJie Jiang, Minghua Li, Bing Zhao, Xing‐Lou Yang
Abstract
• Establishment of 3D cardiac organoids composed of cardiomyocyte and endothelial layers. • SARS-CoV-2 infection causes multi-lineage cardiac injuries. • Cardiovascular health should be greatly concerned in COVID-19 patients.
Topics & Concepts
OrganoidCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMyocarditisVirologyMedicineBetacoronavirusBiologyCardiologyPathologyCell biologyInfectious disease (medical specialty)OutbreakDiseaseCardiovascular Effects of ExerciseMechanical Circulatory Support DevicesCardiovascular Function and Risk Factors