Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting
Pownraj Brindangnanam, Ajit Ramesh Sawant, K Prashanth, Mohane Selvaraj Coumar
Abstract
) pathogens, their multidrug efflux targets and inhibitors are discussed. Deep knowledge about the functioning of efflux pumps and their structural aspects will open up opportunities for developing new EPI, which could be used along with AMA as combination therapy to overcome the emerging AMR crisis.
Topics & Concepts
EffluxBiologyAcinetobacter baumanniiAntimicrobialMicrobiologyPseudomonas aeruginosaEnterococcus faeciumMultiple drug resistanceAntibiotic resistanceStaphylococcus aureusKlebsiella pneumoniaeDrug resistancePopulationMembrane transport proteinBacteriaEscherichia coliTransporterAntibioticsBiochemistryMedicineGeneticsGeneEnvironmental healthAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in Staphylococcus