High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1
Krystian A. Kozek, Andrew M. Glazer, Chai‐Ann Ng, Daniel J. Blackwell, Christian Egly, Loren Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Björn C. Knollmann, Jamie I. Vandenberg, Dan M. Roden, Brett M. Kroncke
Topics & Concepts
Missense mutationPotassium channelhERGLong QT syndromeHEK 293 cellsMedicineCell biologyMutationBiologyBiophysicsGeneticsInternal medicineGeneQT intervalCardiac electrophysiology and arrhythmiasIon channel regulation and functionReceptor Mechanisms and Signaling