Access to 2,2‐Halofluorobicyclo[1.1.1] Pentanes via Non Ozone‐Depleting Ethyl Dihalofluoroacetate
Ziyue Zhu, Jiaqi Tang, Matthew Coe, Alexander Knieb, Yijie Xu, Daniel Lin, Chao Zhang, G. K. Surya Prakash
Abstract
Abstract An operationally simple protocol to access 2,2‐chlorofluoro‐, and 2,2‐bromofluorobicyclopentanes (BCPs) via commercially available, inexpensive, non‐ozone depleting, and bench stable reagents is reported. The resulting BCP products are tolerated in diverse, synthetically relevant post‐functionalization reactions. Gram‐scale reactions to prepare the BCPs are also included.
Topics & Concepts
ChemistryOzoneOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction Mechanisms