Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
Andrea S. Pereyra, Arvind Rajan, Christina R. Ferreira, Jessica M. Ellis
Abstract
mice could be attributed to increases in lipid excretion via feces, GFD15 production, and energy expenditure. L-carnitine supplement intervention lowers acylcarnitines and improves insulin sensitivity independent of muscle mitochondrial fatty acid oxidative capacity. The loss of muscle CPT2 results in a high degree of long-chain acylcarnitine accumulation, simultaneously protecting against diet-induced obesity and insulin resistance.
Topics & Concepts
Insulin resistanceInternal medicineCarnitineEndocrinologyCarnitine O-palmitoyltransferaseLipotoxicityObesityMedicineMyopathyInsulinChemistryBeta oxidationMetabolismDiet and metabolism studiesMetabolomics and Mass Spectrometry StudiesAdipose Tissue and Metabolism