Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem
Xiaoping Yue, Yitong Li, Minjie Liu, Di Sang, Zedu Huang, Fen‐Er Chen
Abstract
. An eight-step synthesis of diltiazem, clentiazem, and siratiazem was accomplished in 32-45% overall yields, featuring this versatile biocatalytic reduction reaction as well as an efficient, green chlorination reaction in flow.
Topics & Concepts
Kinetic resolutionChemistryArylYield (engineering)Substrate (aquarium)DiltiazemCatalysisCombinatorial chemistryReaction conditionsStereochemistryOrganic chemistryEnantioselective synthesisMaterials scienceAlkylCalciumOceanographyGeologyMetallurgyPharmacogenetics and Drug MetabolismChemical synthesis and alkaloidsEnzyme Catalysis and Immobilization