Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression
Ryan Chaban, Ikechukwu Ileka, Gannon McGrath, Kohei Kinoshita, Zahra Habibabady, Madelyn Ma, Victoria Diaz, Akihiro Maenaka, Anthony Calhoun, Megan Dufault, Ivy A. Rosales, Christiana M. Laguerre, S. Sanatkar, Lars Burdorf, David Ayares, William Eyestone, Prachi Sardana, Kasinath Kuravi, Lori Sorrells, Seth Lederman, Caroline Gomes Lucas, Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth, David K. C. Cooper, Richard N. Pierson
Topics & Concepts
CD154ImmunosuppressionBlockadeMedicinePharmacologyIschemiaImmunologyBiologyCardiologyInternal medicineReceptorCD40Cytotoxic T cellBiochemistryIn vitroXenotransplantation and immune responseAnimal Genetics and ReproductionVirus-based gene therapy research