Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease
Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung‐Wing Li, Man Shing Wong
Abstract
level increases age dependently concomitant with the plaque contents. Therefore, this smart probe can act as a powerful tool to diagnose high-risk subjects and diseased brains of AD and to further study the role of ROS in AD pathology.
Topics & Concepts
Reactive oxygen speciesOxidative stressFluorescenceBiophysicsCyanineHydrogen peroxideAmyloid βAmyloid (mycology)ChemistryMaterials scienceBiochemistryBiologyPathologyMedicineDiseaseQuantum mechanicsInorganic chemistryPhysicsAlzheimer's disease research and treatmentsMolecular Sensors and Ion DetectionCholinesterase and Neurodegenerative Diseases