Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors
Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan
Abstract
was potential for developing as antitumor reagent.
Topics & Concepts
ChemistryApoptosisTrifluoromethylReagentA549 cellKinaseStereochemistryCombinatorial chemistryPharmacologyCancer researchBiochemistryBiologyOrganic chemistryAlkylQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms