Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies
Ericka Kirkpatrick Roubidoux, Kaori Sano, Meagan McMahon, Juan Manuel Carreño, Christina Capuano, Kaijun Jiang, Viviana Simon, Harm van Bakel, Patrick C. Wilson, Florian Krammer
Abstract
As improved influenza virus vaccines are being developed, the influenza virus neuraminidase (NA) is becoming an important new target for immune responses. By identifying novel epitopes of anti-NA antibodies, we can improve vaccine design. Additionally, characterizing escape mutations in these epitopes aids in identifying NA antigenic drift in circulating viruses.
Topics & Concepts
EpitopeVirologyNeuraminidaseMonoclonal antibodyBiologyOriginal antigenic sinAntigenic driftVirusAntibodyInfluenza A virusH5N1 genetic structureAntigenAntigenic shiftImmunologyCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)DiseasePathologyInfluenza Virus Research StudiesRespiratory viral infections researchMonoclonal and Polyclonal Antibodies Research